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All term newborns (gestational age ≥37weeks) admitted to the NICU from birth to 72hours of life with signs of respiratory distress and a diagnosis of spontaneous pneumothorax confirmed by chest X-ray (CXR), were included in the study. Newborns with congenital/chromosomal anomalies, history of meconium stained liquor/meconium aspiration, respiratory distress syndrome, transient tachypnea of newborn, pneumonia, tension pneumothorax requiring thoracocentesis or chest tube drainage, those who received positive pressure ventilation (PPV) or mechanical ventilation (MV) before the diagnosis of spontaneous pneumothorax were excluded.

Based on initial fraction of inspired oxygen concentration used at admission for the treatment of SP, neonates were divided into three groups: high fraction of inspired oxygen (FiO)/nitrogen washout (HO: FiO ≥ 60%), moderate oxygen (MO: FiO < 60%) or room air (RA: FiO = 21%). The decision to treat a patient with room air, high or moderate oxygen concentration was based on individual attending neonatologist preference.

The initial concentration of oxygen used for treatment of spontaneous pneumothorax was the primary exposure variable. Duration of oxygen therapy was calculated from the initiation of oxygen therapy until clinical resolution of pneumothorax or till treatment failure (development of tension pneumothorax within 72hours of diagnosis and treatment of SP). Data on maximum O concentration inspired during the treatment period was based on the highest recorded dose documented in the chart. The method of oxygen delivery at the time of admission was either via oxyhood, or nasal cannula. The concentration of inspired oxygen via oxyhood was analyzed through an oxygen analyzer. The concentration of inspired oxygen through nasal prongs was calculated according to the “STOP- ROP effective FiO conversion table” [ AllhqFashion Womens Solid High Heels Round Closed Toe PU Zipper Boots White DDi47r6tp
], a modified equation described by Benaron and Benitz [ 21 ]. The severity of respiratory distress was classified according to the validated “Acute care of at-risk newborn (ACoRN)” respiratory score [ 22 , 23 , 24 ]. The estimation of pneumothorax size was abstracted from the radiologist report; radiologists were blinded to the treatment group. There was no validated method available to measure the size of pneumothorax on CXR in neonates so an estimation was made according to adult guidelines as mentioned in the British Thoracic Society (BTS) guidelines [ Nine Seven Suede Leather Womens Round Toe Chunky Heel Elegant Office Handmade Classy Ankle Booties Burgundy 9WH1ew0
], and from the neonatal literature [ 8 , Converse Kids Chuck Taylor All Star Street Ox Infant/Toddler Charcoal 3OJXhHkKVT
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Clinical resolution of pneumothorax was defined as cessation of respiratory distress and discontinuation of oxygen treatment with maintenance of SpO ≥ 95%. Nitrogen washout was defined in our NICU as the use of 60 to 100% of inspired O continuously for at least 6hours.


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Methods for Evaluation of medical prediction Models, Tests AndBiomarkers (MEMTAB) 2018 Symposium 2-3 July 2018 , Amsterdam, The Netherlands

Stimulating dialogue aiming to tackle the methodological and practical complexities facing the diagnostic, prognostic, screening and monitoring field today, the conference abstracts for this international symposium have been published in

Content type: Meeting abstracts

| 2 July 2018

Methods for Evaluation of medical prediction Models, Tests And Biomarkers (MEMTAB) 2018 Symposium


Content type: Protocol

| 2 July 2018

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Authors: G.-J. Geersing, N. Kraaijpoel, H. R. Büller, S. van Doorn, N. van Es, G. Le Gal, M. V. Huisman, C. Kearon, J. A. Kline, K. G. M. Moons, M. Miniati, M. Righini, P.-M. Roy, S. J. van der Wall, P. S. Wells and F. A. Klok

Content type: Commentary

| 18 June 2018

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Authors: Ann Van den Bruel and Gail Hayward

Content type: Methodology

| 12 June 2018

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Authors: Teus H. Kappen, Wilton A. van Klei, Leo van Wolfswinkel, Cor J. Kalkman, Yvonne Vergouwe and Karel G. M. Moons

Content type: Methodology

| 21 May 2018

Using ordinal outcomes to construct and select biomarker combinations for single-level prediction

Authors: Allison Meisner, Chirag R. Parikh and Kathleen F. Kerr

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Content type: Meeting abstracts

| 16 February 2017

Authors: Gowri Gopalakrishna, Miranda Langendam, Rob Scholten, Patrick Bossuyt, Mariska Leeflang, Anna Noel-Storr, James Thomas, Iain Marshall, Byron Wallace, Penny Whiting, Clare Davenport, Mariska Leeflang, Gowri GopalaKrishna, Isabel de Salis, Sue Mallett, Robert Wolff…

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